Congenital Heart Defect in Dogs
Patent Ductus Arteriosus Dogs
The term PDA conjures up images of handheld mini-computers for most people, but in veterinary cardiology, PDA stands for the condition called patent ductus arteriosus, the most common congenital heart defect in dogs.
So what is a Ductus Arteriosus and why shouldn’t it be Patent?
Everybody had a ductus arteriosus once but it was a long time ago, back in one’s fetal days. As a developing fetus, one depends on one’s umbilical circulation to supply oxygen. After all, not only are the lungs not developed yet but there is no air to breathe inside mom’s uterus. But we still have a heart and it still pumps blood even in the fetal stage. The problem is that we really need the blood to bypass the non-functional lung and that is where the ductus arteriosus comes in. The ductus arteriosus is a small channel connecting the pulmonary artery (which will one day carry blood to the lungs) and the aorta (which already carries blood to the rest of the body). Because the lung is developing, full of fluid, and generally not ready to do anything, blood vessels growing there have high resistance. In other words, it would take a lot of force from the heart to circulate blood there. Since there is a low resistance channel wide open, blood diverts through it instead, by-passing the lungs and circulating through the rest of the fetal body.
At birth, everything changes. We take our first breath. Our lungs begin to work as they were meant to: to exchange gases. They fill with air and the circulatory resistance drops. It then becomes easier for the blood to flow to the lung rather than through the ductus. The ductus closes within the first 3 days of life and is securely closed by day 7 to 10 of life.
Blood now flows the way it is supposed to: from the right side of the heart to the lung to pick up oxygen then back to the left side of the heart to the body to deliver the oxygen.
Or at least that is what is supposed to happen. Sometimes the ductus does not close. It remains open or “patent.” When the ductus stays open, blood from the aorta will want to flow, not to the body but to the low resistance ductus opening and into the pulmonary artery. This is called a left to right shunt and creates an assortment of problems.
Why Left to Right Shunting is Bad
The body has its oxygen requirement and demands to be serviced by the heart. The problem is that a great deal of blood (how much depends on the size of the ductus) is shunting back to the pulmonary circulation. In order to meet the body’s oxygen demand, the heart is going to have to pump all the more blood to cover what circulates in the shunt as well as what the body needs. This is a lot of extra work for the heart and failure can result, leading to coughing, weakness, and difficulty breathing. In fact, more than 25% of pups have some degree of heart failure at the time their patent ductus is discovered.
Treatment for PDA involves surgically tying off of the ductus with a piece of suture or coil.
If this can be accomplished, all the heart problems are reversible.
If heart failure is present, it will need to be controlled with medicine before surgery is possible.
Read about management of heart failure.
If the volume overload to the lung’s circulation is allowed to go on indefinitely (and the patient has not died from heart failure during puppyhood), resistance increases in the lung and the shunt may diminish or even reverse to a right to left shunt. Increased resistance in the lung circulation is called pulmonary hypertension. A right to left shunt is no longer something that can be fixed and the patient will be very sick from heart disease by age 2 to 3.
Diagnosis of PDA
A characteristic murmur can be heard in patients with a patent ductus arteriosus. The murmur is described as sounding like a washing machine and is often called a continuous or “machinery” murmur. Discreet heart “thumps” cannot be made out; only the continuous whooshing of the murmur is heard. The murmur is best heard with the stethoscope positioned in the patients left “arm pit.” If the condition progresses to right to left shunting, no murmur will be heard.
An increased index of suspicion exists for breeds of dogs with a known predisposition to PDA. These breeds include German Shepherd Dog, Miniature Poodle, Keeshond, Cocker Spaniel, Pomeranian, Collie, and Shetland Sheepdog.
The work-up to confirm the presence of the ductus will include chest radiographs to rule out fluid build up from heart failure, and to look for characteristic enlargement of the aorta and the left side of the heart where the extra blood volume is contained. Echocardiography clinches the diagnosis as all the chamber sizes are measured and the patent ductus can actually be seen.
Treatment: Surgical Ligation
This is the traditional method of repair. The chest is opened and a piece of suture is used to tie off the patent ductus.
This surgical ligation is a procedure that not all veterinarians are comfortable performing. Discuss with your veterinarian whether referral to a specialist would be best for you and your pet.
The complication rate is less than 5%, with less than 2% requiring a second procedure due to re-opening of the ductus.
Treatment: Coil Embolization
If the patient is fairly small, a second option exists: percutaneous transarterial coil embolization. Here, coils made of steel and Dacron are placed in the ductus from an external artery in the leg or throat. The coil essentially causes small clots to form and plug the narrow end of the ductus. A 2.4% mortality rate is associated with this procedure. It is appealing as it is less invasive.
Without treatment two-thirds of affected puppies will die before reaching age one year.
tags; congenital heart defect dogs, heart murmur, congenital heart defect dogs, heart failure, congestive heart failure, ventricular septal defect, blood flow, subaortic stenosis, septal defect, blood vessels, aortic stenosis, aortic valve, heart defect, congenital heart defects, septal defect, heart defect, left ventricle, atrial septal defect, ventricular septal defect, oxygen-rich blood, heart murmur, left atrium, patent ductus arteriosus, heart defect, congenital heart defect dogs,