Eosinophilic Granuloma Complex in Cats

A granuloma is a solid grouping of inflammatory cells coming together in a lump or solid structure.

What is an Eosinophil?

An eosinophil is a type of white blood cell that is commonly associated with allergic responses or with parasitism. Eosinophil counts will go up on a blood test when a pet has fleas or worms or when an allergy is flaring up. Eosinophils can circulate in the blood or they can infiltrate tissue. They are part of the immune system and are on patrol for biochemical signals from tissue (calls for help, if you will) telling them that a parasite has invaded. Eosinophils home to the signal and release chemicals to attack the parasite. Unfortunately, they can be tricked into thinking that some sort of benign materials (pollens, dust, etc.) are attempting invasion. In this instance (allergy), they release their inflammatory chemicals inappropriately, creating the sensations of itching, swelling, redness and other symptoms of allergy.

The eosinophil has a characteristic appearance under the microscope due to the pink staining granules. The pink staining granules contain assorted toxins and biochemicals designed to attack an invading parasite. These granules can be thought of as small bombs directed against large invading organisms such as worms.

So what is Eosinophilic Granuloma Complex?

Given the above information it would seem logical that an eosinophilic granuloma would be a granuloma made up of eosinophils; however, the situation is more complicated. Initially, it appeared that eosinophilic granuloma was just what it sounds like but as it was studied more thoroughly, it was found that there were three different classes of this condition and not all were granulomas and not all involved eosinophils. Furthermore, the name eosinophilic granuloma implies a final diagnosis but this is generally not the case. Eosinophilic granuloma lesions are more like symptoms of a variety of underlying causes such as allergy or even bacterial infection.

The three classes of eosinophilic granuloma complex are listed below and an individual cat may have any or all of them. The three classes are:

  • the indolent ulcer
  • the eosinophilic plaque
  • the eosinophilic granuloma.

These conditions are felt to most commonly have an underlying allergic basis though it is not always possible to determine what that allergic basis might be. The presence of any of the three above conditions does not definitively imply any specific type of allergy. In fact, there is some evidence that some cases begin as simple allergic reaction to an external substance but when internal skin proteins are released by scratching, the reaction continues to involve these “self” proteins as well.

The Indolent Ulcer (also called the rodent ulcer)

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Cats with indolent ulcers have an erosion on the margin of their upper lip. Sometimes, a proliferative eroded structure also develops on the tongue so if your cat has a classical lip ulcer, it is a good idea to open the cat’s mouth and check the tongue yourself.

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In general, the appearance of the indolent ulcer is classical and a biopsy is not needed; though occasionally these are precancerous conditions and biopsy may be needed to rule out a malignant skin tumor. If allowed to go untreated, the ulcer can be very destructive to the upper lip. Even after treatment, the ulcer will likely heal but the area of lip that has been destroyed will not grow back and the cat’s face will be permanently altered.

The Eosinophilic Plaque

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This lesion typically looks like a raised thickened raw area of skin usually on the belly, inner thigh, anal, or throat area. Cats with these lesions are commonly extremely itchy. A microscope slide pressed onto the affected area often picks up numerous eosinophils that can be detected under the microscope, thus confirming this condition. Cats with this condition generally have increased circulating eosinophils in their bloodstreams as well.

The Eosinophilic Granuloma (also called the linear granuloma or collagenolytic granuloma)
The eosinophilic granuloma produces a classical swollen lower lip or chin or a classical long, narrow lesion running down the back of the thigh. Sometimes proliferations grow from the actual footpads where they ulcerate as the cat is forced to walk on them. There is some tendency for this condition to occur in adolescent kittens though it can occur at any age.

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The eosinophilic granuloma complex represents a disorder of eosinophil function. The eosinophil’s real job is to attack parasites. It is designed to be attracted to areas where parasitism is occurring and once there it releases biochemicals to destroy the invading creature. In cats with eosinophilic granuloma complex, eosinophils are called to the site of an allergic response and the biochemicals released cause damage to local collagen. As mentioned, the reaction can include “self” proteins as well as external ones.


In most cases, the eosinophilic granuloma responds to cortisone-type medications. Typically an injection of long-acting corticosteroid (such as Depomedrol®) is given and most lesions resolve with one or two injections. As long as such treatment is needed only once or twice a year for recurrences, more exotic medications or diagnostics are not needed. Oral steroids are less altering to the cat’s overall metabolism and are probably a healthier alternative but giving regular oral medication to a cat is sometimes easier said than done.

Cyclosporine, an immunomodulating oral medication, has also been effective and might be a good alternative especially for a cat that cannot take steroids because of some other condition (incompatible other medication, concurrent diabetes mellitus, concurrent heart disease etc.)

Lesions that are more refractory are another story. Biopsy may be needed to confirm the diagnosis of eosinophilic granuloma; tumors or other ulcerative lesions may mimic the eosinophilic granuloma complex. Biopsy may also tweak out less obvious underlying causes such as demodex mites or ringworm fungi. (Keep in mind eosinophilic granuloma represents an inflammatory reaction to proteins deemed foreign by the eosinophils). If it is at all possible, the underlying cause (allergy etc.) should be addressed. If it is not, the eosinophilic granuloma complex lesions will undoubtedly recur.

The eosinophilic granuloma is an incompletely understood condition. For now it is best to view it as an extreme symptom of another underlying skin disease.

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